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3.1- Homogeneous Mixing

In the homogeneous mixing scenario, each cell is a neighbor of every other cell. Such a world can be pictured as a fully-connected graph in which the nodes represent cells and the arcs represent connections (neighbor-relationships) between them. This topology and numerous variations on it have been favored by theorists for many decades -- mainly for reasons of analyzability rather than realism. In this topology, the question of which nodes are infected has no bearing on the overall population dynamics; all that matters is how many are infected. Thus, as was stated earlier, topology is virtually eliminated as a consideration.

If the number of nodes is very large, stochastic effects can be ignored, and the problem can be treated deterministically. In this case, the fraction of infected nodes as a function of time, a(t), can be obtained by solving a simple nonlinear differential equation [1]:

 

equation60

the solution to which is

 

equation65

where tex2html_wrap_inline543 and tex2html_wrap_inline545 .

The solution given by Eq. 2 reveals that, when the death rate tex2html_wrap_inline527 exceeds the birth rate tex2html_wrap_inline525 ( tex2html_wrap_inline551 ), the fractional population of A decays exponentially from its initial value. Thus extinction is inevitable. However, when the birth rate exceeds the death rate, the fraction of infected nodes grows exponentially at first and then saturates at the value tex2html_wrap_inline555 . An example of such behavior is illustrated in Fig. 1, which depicts a(t) for tex2html_wrap_inline457 and tex2html_wrap_inline459 , starting from an initial condition a(0)=0.0001. (If the initial fractional population exceeds the equlibrium value, a(t) decays to the equilibrium at an exponential rate.)

Thus there is a sharp ``epidemic threshold'' such that the population survives if the birth rate exceeds the death rate and is driven to extinction otherwise gif. The existence of the epidemic threshold was first derived about 60 years ago, and has been perhaps the most powerful paradigm in theoretical epidemiology [15].

In systems of finite size, probabilistic analysis reveals that, even above the threshold, the population has some chance of becoming extinct, but only if the initial number of infected nodes is small enough to be vulnerable to statistical fluctuations [1]. For example, starting from an initial condition in which one cell is occupied by A, the probability that the population will survive is tex2html_wrap_inline555 . Having established these basic facts about homogeneous mixing in Model 1, we can now turn to other topologies for comparison.


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